| Evaluation of Tissue Factor and CD146 among Egyptian Type 2 Diabetic Patients |
| Paper ID : 1137-ISCHU |
| Authors |
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Ebtisam Fahmy * Faculty of Science Helwan university |
| Abstract |
| Diabetes mellitus which became the century’s illness is characterized by hyperglycemia which increases the risk of atherogenesis leading to endothelial dysfunction. The study supported the correlation between tissue factor (TF) and Cluster of differentiation 146 (CD146) with type 2 diabetes. TF is an initiator of the development of thrombotic complications. Circulating endothelial cells, marker of endothelial dysfunction, detected by estimation of CD146. Aim of work: to evaluate the correlation between TF and CD146 among Egyptian patients of type 2 diabetes with some of disease complications. Patients & methods: It is a case – control study that was conducted on 59 subjects whose age ranged 40 – 60 years old, divided into three main groups: nondiabetic, pre-diabetic and T2D cases. Each main group was categorized into two sub groups: with or without cardiovascular diseases (CVD). They all underwent full history taking, clinical examination including blood pressure, anthropometric measurements waist circumference and body mass index (BMI), laboratory tests including fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), lymphocytes, monocytes, neutrophils, platelets, total cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG). While very low density lipoprotein cholesterol (VLDL-C) and atherogenesis were calculated be equations. TF and CD146 were determined by enzyme linked immunosorbent assay (ELISA) technique. 2 Results: Plasma TF levels showed a highly significant increase in cases of T2D with CVD by 188.3%. For Serum CD146, a significant increase was observed in cases of T2D with CVD by 202.3%. Conclusion: The findings in the current study supported the hypothesis that endothelial dysfunction may be a common pathogenic precursor to CVD and Type 2 Diabetes, placing endothelial dysfunction as a fundamental abnormality in the insulin resistance syndrome |
| Keywords |
| Diabetes Mellitus; Type 2 Diabetes; Atherogenesis; Endothelial Dysfunction; Tissue factor; Cluster of differentiation 146 |
| Status: Abstract Accepted (Poster Presentation) |