| The Potential Role of Coriandrum Sativum Oil on Acrylamide |
| Paper ID : 1125-ISCHU |
| Authors |
|
Shimaa Elsayed Orabi * Faculty of Science
Helwan University |
| Abstract |
| In order to test Coriandrum sativum oil's (CSO) anti-inflammatory, antioxidant, and anti-apoptotic characteristics versus ACR-induced oxidative stress and hepatotoxicity in male rats, this study is being conducted. Rats were placed into four equal groups: the control group, the ACR-treated group received ACR at 25 mg/kg, the CSO-treated group received CSO at 600 mg/kg, and the CSO group that had also received ACR. Physiological indicators of liver function, inflammatory reactions, oxidative stress, and apoptosis in liver homogenates were assessed after 21 days of treatment. The current findings showed that following ACR treatment, body weight significantly decreased and blood liver enzymes significantly increased. Malondialdehyde and nitric oxide levels were elevated significantly in the liver in response to ACR, while superoxide dismutase, catalase activity, and glutathione levels were decreased significantly. Nuclear factor-κB, tumour necrosis factor-alpha, and interleukin 1 beta in liver tissue were also significantly raised. The pro-apoptotic markers Bax and caspase-3 were also significantly elevated after ACR intoxication. Furthermore, ACR intoxication significantly decreased Bcl-2 levels, an anti-apoptotic protein. Hepatotoxicity, oxidative stress, inflammation, and apoptosis brought on by ACR toxicity were lessened significantly with CSO treatment. Overall, this study's findings point to the significance of CSO in restricting the hepatotoxicity that ACR caused. |
| Keywords |
| Acrylamide; Coriandrum sativum oil; Hepatotoxicity; Inflammation; Oxidative stress. |
| Status: Abstract Accepted (Oral Presentation) |