Effect of melatonin on sepsis induced nephrotoxicity

Paper ID : 1097-ISCHU

Authors

Amina Fawzy Hussein *, Ahmed Esmat Abdel Moneim, Mohga Shafik Abdallah, Rasha Salah Mohamed Helwan University

Abstract

Sepsis is a very hazardous clinical condition that can result in abnormalities in tissue perfusion, organ failure, shock, and even death. Despite the fact that source control and antibiotics are the mainstays of sepsis treatment, it is also one of the most expensive illnesses in the world. Given the high mortality rate, sepsis must be effectively treated medically. Stem cell therapy is a highly advanced and promising area of scientific research that has raised significant hopes for the advancement of therapeutic approaches. In this study, we'll demonstrate how MSCs can lessen the harm done by sepsis infection by promoting macrophage microbial phagocytosis and destruction. MSCs may lessen sepsis-induced damage and/or restore function in a variety of organs by altering the immune system to reduce harm to the host and maintain the microorganism-induced immune response. They may do this by enhancing tissue regeneration and restoration following sepsis or enhancing the release of antimicrobial peptides. Melatonin-based stem cell enhancement has produced excellent and encouraging outcomes. Melatonin has a wide range of applications. Because of its anti-oxidative and anti-inflammatory potentials, melatonin has shown to be a potential compound that can be used to treat sepsis damage. Treatment with MSC and MSC enhanced with melatonin increased lifespan and significantly decreased markers of oxidative stress, inflammation, and apoptosis. Kidney segment histological analyses also showed tissue improvements following the therapy. In conclusion, the data showed that by reducing inflammatory, oxidative, and apoptotic indicators, MSC might modify immunological responses brought on by sepsis-induced kidney damage.

Keywords

sepsis, melatonin, MSC, kidney injury

Status: Abstract Accepted (Poster Presentation)