| The Effect of Industrial Air Pollution on Oxidative Stress and Histopathological Alternation on the Liver of Adult Male Albino Mice |
| Paper ID : 1093-ISCHU |
| Authors |
|
Ghada Elsayed Fahem * Helwan university faculty of sience |
| Abstract |
| Air pollution occurs when chemicals or biological matter that can harm humans or other living things are introduced into the atmosphere. Therefore, this study aimed to investigate the effects of oxidative stress and histopathological alterations in hepatic tissues of adult male albino mice whose exposure to air pollution during the duration of their living in the atmosphere of The Egyptian Company for Aluminium Products –Alumisr Wadi Houf. The current study involved forty-five healthy adult male Swiss albino mice living in the determined site in the Alu Misr factory for a month, and 5 mice from this group were taken every week throughout the month and were dissected in the physiological laboratories of the college. Animals were divided into three groups each group was divided into 4 subgroups (5 mice/subgroup) as follows: The first group: lived close to the anodizing yard (oxidation line) in the Alumisr factory in Helwan (20 mice), The second group: lived close to the foundries (ovens) in the Alumisr factory in Helwan (20 mice) and The third group: lived in physiology lab in Helwan University as a control Site (5 mice). The data recorded in the present study indicated that exposure of experimental mice to industrial air pollution led to toxicity and deformities of the mice tissues; The increase in toxicity was observed with the increase in the period of living in the factory and exposure to industrial air pollution, and this was inferred from oxidative stress confirmed by an increase in nitric oxide level in liver tissues; and accompanied by decrease in glutathione content and catalase activity. In parallel, the histopathological changes were observed in liver tissues. These results indicated that industrial air pollution has a toxic effect on the liver in experimental animals, but further studies are needed to support these findings. |
| Keywords |
| Industrial Air Pollution, Oxidative Stress, Catalase, Glutathione, Nitric Oxide. |
| Status: Abstract Accepted (Poster Presentation) |