| Leukemia is a kind of cancer that affects the blood and bone marrow, resulting in the uncontrolled proliferation of abnormal white blood cells (WBCs). Anti-leukemic chemotherapy (cyclophosphamide, CP) has a number of side effects, including hepatotoxicity and nephrotoxicity. The purpose of this study was to look into the therapeutic effect of Camellia sinensis extract (CSE) on caused leukemia in adult male rats. Following leukemia induction with benzene injection, both healthy and leukemic rats were separated into four groups of ten rats each: 1) untreated control rats, 2) induced- leukemia rats, 3) leukemia rats treated orally with (350 mg/kg) daily CSE for 4 weeks, and 4) leukemia rats treated intraperitoneally with CP (7.5 mg/kg/48 hr.) for 4 weeks. At the conclusion of the experiment, the rats were slaughtered. Hematological markers were assessed, including the total blood count. The results showed that treating leukemic rats with CSE effectively alleviated the leukemic complication signs, as evidenced by a significant reduction in WBCs count; additionally, CSE significantly improved histo-pathological alterations in the spleen, restoring normal area percent of collagen fibers, PAS-stained general carbohydrates, and Myeloperoxidase-positive stained splenocytes in a benzene-induced leukemia model. It is possible to conclude that CSE has antileukemic potential, making it a promising treatment option for leukemia. |
