| Hypoglycemic efficacy of metformin hydrochloride bound liposomes in normal rats |
| Paper ID : 1069-ISCHU |
| Authors |
|
Hesham M. Othman1, Wael M. Elshemey2, Medhat W. Shafaa *3 1Physiological Optics Unit, Basic Science Department, Research Institute of Ophthalmology, Giza, Egypt 2Department of Physics, Faculty of Science, Islamic University of Madinah, Medina, Kingdom of Saudi Arabia 3Medical Biophysics Division, Physics Dept., Faculty of Science, Helwan University |
| Abstract |
| The goal of the current study was to formulate liposomes containing metformin hydrochloride for a sustained drug delivery system. Metformin is frequently used to treat diabetes. Transmission electron microscopy (TEM), particle size, polydispersity, zeta potential, and Fourier transform infrared (FTIR) spectroscopy were used to physically characterize the proposed formulations. The work also assesses the metformin and liposome combination's ability to improve and prolong the hypoglycemic impact in Wistar rats. After Metformin was encapsulated in liposomes, FTIR analysis showed that the structure of the vesicles had changed. By monitoring the glucose levels in healthy rats, the bioavailability of metformin-loaded liposomes as opposed to the free medication was measured and evaluated. After being administered intraperitoneally, liposomal metformin had a gradual hypoglycemia impact that peaked 8 hours later. In comparison to free metformin solution, the metformin-loaded liposomal formulation showed a significantly longer pharmacological action and an enhanced hypoglycemic impact in the efficacy study. |
| Keywords |
| Metformin hydrochloride; Liposomes; FTIR; hypoglycemic effect |
| Status: Abstract Accepted (Oral Presentation) |