| Mersaquinone, A New Tetracene Derivative from the Marine-Derived StreptoMyces sp. EG1 Exhibiting Activity against Mersaquinone, A New Tetracene Derivative from the Marine-Derived Streptomyces sp. EG1 Exhibiting Activity against Methicillin- |
| Paper ID : 1066-ISCHU |
| Authors |
|
Hala Asklany Mohamed *1, Mohamed saleh Abdelfattah2 1Moasast elnour 2Natural Products Research Unit (NPRU), Chemistry Department, Faculty of Science, Helwan University |
| Abstract |
| Methicillin-resistant Staphylococcus aureus (MRSA) is an infectious Gram-positive bacterium that is widely distributed worldwide in hospitals, convalescent homes and community settings [1]. It causes serious infections to the skin and soft tissues and also systemic infections that are responsible for significant mortalities [2–4]. MRSA is multidrug resistant and has evaded successful control [5]. Consequently, discovery of new antibiotics is urgently needed to control MRSA infections so, New antibiotics are desperately needed to overcome the societal challenges being encountered with methicillin-resistant Staphylococcus aureus (MRSA). In this study, a new tetracene derivative, named Mersaquinone (1), and the known Tetracenomycin D (2), Resistoflavin (3) and Resistomycin (4) have been isolated from the organic extract of the marine Streptomyces sp. EG1. The strain was isolated from a sediment sample collected from the North Coast of the Mediterranean Sea of Egypt. The chemical structure of Mersaquinone (1) was assigned based upon data from a diversity of spectroscopic techniques including HRESIMS, IR, 1D and 2D NMR measurements. Mersaquinone (1) showed antibacterial activity against methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 3.36 µg/mL. |
| Keywords |
| MRSA; marine actinomycetes; Streptomyces sp.; anthraquinone; spectroscopy |
| Status: Abstract Accepted (Poster Presentation) |