Bioactive Natural Products from the Red Sea Microorganisms

Paper ID : 1014-ISCHU

Authors

Mohamed Saleh Abdelfattah * Ain Helwan

Abstract

The marine environment contains a great variety of microorganisms living in extreme conditions such as high salinity, pressure, and temperature. These microorganisms were reported to produce unique and structurally novel secondary metabolites, allowing their survival in such conditions. Among such microorganisms, are Gram-positive actinomycetes, which are known to produce secondary metabolites with a wide range of biological activities, including antimicrobial, antimalarial, and antitumor. From an ecological point of view, actinomycetes can be found in several marine environments, such as oceans, rivers, and seas. The Red Sea is one of the most spectacular coastal and marine environments in Egypt and has a rich biodiversity. In this work, we isolated several actinomycetes strains from different sediments and seawater samples collected from the Red Sea coast in Egypt. Different aromatic metabolites with anticancer and antimicrobial activities have been isolated, purified by several chromatographic methods, and their structures have been elucidated by different spectroscopic methods.

Keywords

Red Sea, Sediments, Sponges, Actinomycetes, Histone deacetylase, Anticancer

Status: Abstract Accepted (Oral Presentation)